Iodine-Zinc Exchange Reactions Mediated by i-Pr2Zn. A New Preparation of Secondary Zinc Reagents

DOI: 10.1055/s-1997-760

Source and publish data:

Synlett p. 327 - 328 (1997)

Update date:2022-08-16

Topics:

Authors:

Micouin, Laurent

Knochel, Paul

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Article abstract of DOI:10.1055/s-1997-760

By treatment with i-Pr₂Zn, functionalized secondary alkyl iodides undergo a smooth iodine-zinc exchange reaction leading to polyfunctional secondary dialkylzinc derivatives. Remarkably, i-Pr₂Zn generated in situ from i-PrMgBr and ZnBr₂ undergoes this exchange reaction almost 200 times faster than salt free i-Pr₂Zn and constitutes a practical source of i-Pr₂Zn for the performance of exchange reactions.

Full text of DOI:10.1055/s-1997-760

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