Iodine-Zinc Exchange Reactions Mediated by i-Pr2Zn. A New Preparation of Secondary Zinc Reagents

Article abstract of DOI:10.1055/s-1997-760

By treatment with i-Pr₂Zn, functionalized secondary alkyl iodides undergo a smooth iodine-zinc exchange reaction leading to polyfunctional secondary dialkylzinc derivatives. Remarkably, i-Pr₂Zn generated in situ from i-PrMgBr and ZnBr₂ undergoes this exchange reaction almost 200 times faster than salt free i-Pr₂Zn and constitutes a practical source of i-Pr₂Zn for the performance of exchange reactions.