Synthesis of 5-(2-pyren-1-yl-ethylenyl)-2′-dU as a fluorescent probe for studying electron transfer in DNA

Article abstract of DOI:10.1515/HC.2005.11.3-4.241

This paper describes the synthesis of 5-(2-(pyren-1-yl-ethylenyl)-2′- deoxyuridine (PEdU) based on complete, selective reduction of the ethynyl linker in 5-(2-(pyren-1-yl-ethynyl)-2′-deoxyuridine. It also describes a reliable route for making the 1-ethynylpyrenyl intermediate based on a number of attempts to use previously reported procedures.

Full text of DOI:10.1515/HC.2005.11.3-4.241

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