A NEW AND SIMPLE SYNTHESIS OF ALKOXY- AND ARYLOXYMETHYLLITHIUM REAGENTS (ROCH2Li)

Article abstract of DOI:10.1016/S0040-4039(00)88124-1

A series of halomethyl alkyl and aryl ethers can be converted to the corresponding organolithium reagents (ROCH2Li) in a one-flask operation by sequential treatment (1) with stannous chloride-lithium bromide complex in tetrahydrofuran (THF) and (2) with n-butyllithium.