4'-Methyloxycarbamyl-3'-deoxy-5-methyluridine; synthesis of a novel nucleoside analogue

DOI: 10.1016/0040-4020(95)00020-9

Source and publish data:

Tetrahedron p. 2719 - 2728 (1995)

Update date:2022-08-12

Topics:

Authors:

Pickering

Malhi Malhi

Coe Coe

Walker Walker

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Article abstract of DOI:10.1016/0040-4020(95)00020-9

The preparation of 4'-methyloxycarbamyl-3'-deoxythymidine from chiral amino acid precursors is described. The route chosen employs a hitherto unreported electrochemical oxidation of a suitably protected derivative of trans-4-hydroxy-L-proline, to obtain the key intermediate compound. Conventional condensation methodology is then used to arrive at the target nucleoside.

Full text of DOI:10.1016/0040-4020(95)00020-9

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