4'-Methyloxycarbamyl-3'-deoxy-5-methyluridine; synthesis of a novel nucleoside analogue

DOI: 10.1016/0040-4020(95)00020-9

Source and publish data:

Tetrahedron p. 2719 - 2728 (1995)

Update date:2022-08-12

Topics:

Authors:

Pickering

Malhi Malhi

Coe Coe

Walker Walker

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4020(95)00020-9

The preparation of 4'-methyloxycarbamyl-3'-deoxythymidine from chiral amino acid precursors is described. The route chosen employs a hitherto unreported electrochemical oxidation of a suitably protected derivative of trans-4-hydroxy-L-proline, to obtain the key intermediate compound. Conventional condensation methodology is then used to arrive at the target nucleoside.

Full text of DOI:10.1016/0040-4020(95)00020-9

Products guided by the article

Product name:trans-4-Hydroxy-L-proline methyl ester hydrochloride

Cas No:40216-83-9

R&D Labs maybe for 40216-83-9

Chongqing KonAo Health Co.,Ltd

Contact:13687578375

Address:wuhan hubei china
China Synchem Technology Co.,Ltd

website:http://www.cnsynchem.com

Contact:+86-0552-4929311

Address:No.217 Daqing Road
ShiJiaZhuang Dowell Chemical Co.,Ltd.

website:http://www.dowechem.com

Contact:+86-13463963265

Address:Xiyangling village, high tech Zone, Shijiazhuang，Hebei, China
HANWAYS CHEMPHARM CO.,LIMITED

website:http://www.hanwayschem.com

Contact:+86-18502787239(whatsapp)-

Address:18-1-802, Green Garden, Jianghan District, Wuhan 430023, China
ShenZhen InnoSyn Biotech Co.,Ltd

website:http://www.innosyns.com

Contact:+86-755-28351685

Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District

Relevant to this article

Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives

Doi:10.1021/jm00158a026
(1986)
Redox Chemistry of Dichlorophosphorus(V)tetraphenylporphine: Isolation and Characterization of a Stable Porphyrin 'Anion' Radical and Possible Evidence for Internal Electron Transfer.

Doi:10.1039/c39820001279
(1982)
Trans -A₂B-corrole bearing 2,3-di(2-pyridyl)quinoxaline (DPQ)/phenothiazine moieties: Synthesis, characterization, electrochemistry and photophysics

Doi:10.1039/c8nj00606g
(2018)
Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists

Doi:10.1016/j.bmc.2018.05.036
(2018)
Direct amide formation in a continuous-flow system mediated by carbon disulfide

Doi:10.1039/d0cy01603a
(2020)
The direct conversion of aromatic nitro compounds to isocyanates by carbon monoxide

Doi:10.1016/S0040-4039(00)90615-4
(1967)

Article Doi