Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8

DOI: 10.1016/S0960-894X(98)00635-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3505 - 3510 (1998)

Update date:2022-08-05

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Authors:

Aronov, Alex M.

Gelb, Michael H.

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Article abstract of DOI:10.1016/S0960-894X(98)00635-0

A number of 5', N⁶- and C⁸, N⁶-disubstituted adenosine analogs was synthesized and tested for inhibition of trypanosomal glyceraldehyde 3- phosphate dehydrogenase. The most active compound, N⁶-(3-methyl-2-buteny

Full text of DOI:10.1016/S0960-894X(98)00635-0

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