Chemical and Pharmaceutical Bulletin p. 2122 - 2124 (1997)
Update date:2022-08-10
Topics:
Matsuo, Jun-Ichi
Koga, Kenji
Enantioselective alkylation at the α-position of phenylacetic acid (1) can be realized in up to 68% ee by treating the dilithiated 1 with alkyl halides in the presence of a chiral bidentate lithium amicle ((R)-3).
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