Tetrahedron Letters p. 5743 - 5746 (1998)
Update date:2022-08-25
Topics:
Durand, Jean-Olivier
Larcheveque, Marc
Petit, Yves
A short stereoselective synthesis of (-)-(2S,3S)-3-hydroxyproline has been realized from L-malic acid as the source of chirality. The key step was the reductive cyanation of the intermediate 1a, in high stereoselectivity and yield.
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