Heterocycles p. 293 - 300 (1995)
Update date:2022-08-16
Topics:
Bringmann, Gerhard
Ledermann, Alfons
Francois, Guido
The first total synthesis of a (potential) dimeric carbazole alkaloid is described.After an improved preparation of the monomeric building block, 'biomimetic dimerization' by oxidative phenolic coupling was best achieved with di-tert-butyl peroxide in chlorobenzene, leading to a highly selective formation of the 2,2'-coupled 'dimer', the parent framework of several naturally occurring dimeric carbazole alkaloids.For the atropoenantiomer analysis, a chromatographic procedure on chiral phase was developed.Both the mono- and the dimeric phenolic carbazoles displayed in vitro antimalarial activity against Plasmodium falciparum.
View More
Shanghai Dynamic Industrial Co.,Ltd.
website:http://www.shdynamic.com
Contact:86-021 3392 6680
Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China
LIAOYANG WANRONG CHEMICALS COMPANY LIMITED
Contact:86-419-2390789
Address:XINLI VILLAGE , DONG NINGWEI COUNTY,TAIZIHE DISTRICT, LIAOYANG , LIAONING
SHENYANG COMEBOARD TECHNOLOGY CO., LTD
Contact:+86-24-25724626
Address:Room2210,Tianbao International Building,No.8-1 Weigong South Street,Tiexi District,Shenyang,China
Contact:13357117572
Address:No.149 Shiji dadao Road.
Suzhou Sinosun Imp.&Exp. Corporation
website:http://www.szsinosun.com
Contact:+86-512-63488895,63488616
Address:No.758 East Jiangling Road Wujiang Economic & Technological Developmenty Zone Jiangsu China
Doi:10.1016/S0040-4039(01)99528-0
(1965)Doi:10.1007/s13738-015-0592-1
(2015)Doi:10.1016/S0022-1139(00)85147-7
(1980)Doi:10.1016/j.bmcl.2020.127187
(2020)Doi:10.1016/j.tetlet.2013.09.055
(2013)Doi:10.1007/BF00953886
(1987)
