Molecules (2016)
Update date:2022-08-11
Topics:
Mabkhot, Yahia N.
Aldawsari, Fahad D.
Al-Showiman, Salim S.
Barakat, Assem
Soliman, Saied M.
Choudhary, Muhammad I.
Yousuf, Sammer
Hadda, Taibi Ben
Mubarak, Mohammad S.
A novel thiophene-containing compound, 2-acetyl-3-amino-5-[(2-oxopropyl)sulfanyl]-4- cyanothiophene (4) was synthesized by reaction of malononitrile with CS2 in the presence of K2CO3 under reflux in DMF and the subsequent reaction with chloroacetone followed by cyclization. This compound has been characterized by means of FT-IR, 1H-NMR, 13C-NMR, and mass spectrometry as well as elemental analysis. In addition, the molecular structures of compound 4 was determined by X-ray crystallography. The geometry of the molecule is stabilized by an intramolecular interaction between N1-H1? O1 to form S6 graf set ring motif. In the crystal, molecules are linked via N1-H2? O1 and C7-H7A?N2 interactions to form a three-dimensional network. Molecular structure and other spectroscopic properties of compound 4 were calculated using DFT B3LYP/6-31G (d,p) method. Results revealed a good agreement between the optimized geometric parameters and the observed X-ray structure. Furthermore, and by employing the natural bond orbital (NBO) method, the intramolecular charge transfer (ICT) interactions along with natural atomic charges at different sites, were calculated; results indicated strong n=π? ICT from LP(1)N5?BD?(2)C15-C16 (63.23 kcal/mol). In addition, the stabilization energy E(2) of the LP(2)O3→BD?(1)N5-H6 ICT (6.63 kcal/mol) indicated the presence of intramolecular N-H?OH bonding. Similarly, calculations of the electronic spectra of compound 4 using, TD-DFT revealed a good agreement with the experimental data. Finally, compound 4 was evaluated for its in vitro cytotoxic effect against PC-3 and HeLa cell lines, as an anticancer agent, and found to be nontoxic.
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Doi:10.1021/ja00049a029
(1992)Doi:10.1080/00397911.2013.857690
(2014)Doi:10.1007/BF01495114
(1934)Doi:10.1002/zaac.201500812
(2016)Doi:10.1021/ja00709a067
(1970)Doi:10.1016/S0304-4149(99)00076-9
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