Total Synthesis of the Lipid-Altering and Antiatherosclerotic Furochromone Khellin. The Furoic Acid Route to Highly Functionalized Benzofurans

DOI: 10.1021/jo00169a069

Source and publish data:

Journal of Organic Chemistry p. 3863 - 3865 (1983)

Update date:2022-08-29

Topics:

Authors:

Gammill, Ronald B.

Hyde, Bruce R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00169a069

3-Furoic acid is converted to enaminone diester 8, which undergoes Dieckmann cyclization to yield the highly functionalized benzofuran 9.Methylation, Baeyer-Villager oxidation (CHO -> OH) and conversion of the resulting hydroxy ester 10 to khellinone constitutes a formal synthesis of khellin.

Full text of DOI:10.1021/jo00169a069

Products guided by the article

Product name:KHELLINONE

Cas No:484-51-5

R&D Labs maybe for 484-51-5

Wuxi Forest Biological Co.,Ltd

Contact:+86-510-81602300

Address:Room 317,Building D, No.159 middle Chengjiang Road,Jiangyin Wuxi city.
SHANXI JINJIN CHEMICAL INDUSTRIAL CO.,LTD

website:http://www.jinjingroup.com

Contact:86-574-13989382828

Address:Economic And Technological Development Zone,Hejin?City,Shanxi Province?,China
Shanghai Bojing Chemical Co., Ltd.

Contact:021-37122233

Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.
puyang hongda shengdao new material co.,ltd.

Contact:+86-393- 4896278

Address:No.29 East Zhongyuan Road
Jinan Finer Chemical Co., Ltd

website:https://www.finerchem.com

Contact:+86-531-88989536

Address:New Material Industrial Park, Jinan City, China

Relevant to this article

Iodine, a Mild Reagent for the Aromatization of Terpenoids

Doi:10.1021/acs.jnatprod.5b00914
(2016)
Doi:10.1021/ja01334a004
(1933)
A hydrogen-bonded dimer of a novel Co(II) complex of monoethanolamine with thiocyanate: Synthesis, spectra, thermal behaviour and crystal structure

Doi:10.1016/S0022-2860(02)00105-9
(2002)
Temperature-Dependent Stereoselectivity and Hydrogen Deuterium Kinetic Isotope Effect for γ-Hydrogen Transfer to 2-Hexyloxy Radical. The Transition State for the Barton Reaction

Doi:10.1021/ja00269a040
(1986)
On thermodynamic characteristics of In-I system compounds thermodynamische daten von indiumiodid

Doi:10.1002/(SICI)1521-3749(199906)625:6<1013::AID-ZAAC1013>3.0.CO;2-8
(1999)
Stereoselectivity in Oxidative and Reductive Transformations of p-Menthane Derivatives with the Cultured Cells of Nicotiana tabacum

Doi:10.1246/cl.1987.903
(1987)

Article Doi