EREMOPHILENOLIDES FROM PETASITES JAPONICUS

Article abstract of DOI:10.1016/S0031-9422(00)81060-2

Key Word Index - Petasites japonicus; Compositae; Senecioneae; sesquiterpene lactones; eremophilenolides; 13C NMR; CD spectra. - Chemical investigation of the young flower stalks of Petasites japonicus afforded some eremophilenolides, including a mixture of the two new compounds 6β-angeloyloxy-3β,8α-dihydroxyeremophil-7(11)-en-12,8β-olide and 6β-angeloyloxy-3β,8β-dihydroxyeremophil-7(11)-en-12,8α-olide.Their structures were elucidated by chemical and spectroscopic methods.The 13C NMR signals for the carbon atoms of the eremophilenolides were assigned with the help of Beierbeck's parameters.The CD spectra of the compounds are briefly discussed.