Chemical and Pharmaceutical Bulletin p. 1273 - 1275 (1996)
Update date:2022-08-11
Topics:
Sagi, Kazuyuki
Kagechika, Hiroyuki
Fukasawa, Hiroshi
Hashimoto, Yuichi
Shudo, Koichi
A strategy for development of thyroid hormone analogs was examined based on the combinatorial concept. The reaction of ethyl 3,3',5- triiodothyroacetate (3b) with Cd/Br2CF2/CuBr followed by ester hydrolysis gave a mixture of more than ten products as detected by HPLC. The structures of the products in the bioactive fractions showed that the replacement of iodides with trifluoromethyl groups is an effective approach for obtaining thyromimetics.
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