Experiments Directed Towards the Synthesis of Anthracyclinones. XXVI. The Preparation of Chiral Intermediates for Anthracyclinone Synthesis

Article abstract of DOI:10.1071/CH9950669

(2'R)-1,5-Dimethoxy-2-(2'-methyloxiran-2'-ylmethyl)anthraquinone (8), an intermediate for the synthesis of fridamycin E, has been prepared enantioselectively via the diol (15).The diol (15) was prepared in high yield by asymmetric cis-hydroxylation of the alkene (11).The analogous diol (22), a vineomycinone B₂ precursor, was also prepared.