ULTRASOUND IN ORGANIC SYNTHESIS 10. SELECTIVE ORTHO-LITHIATION OF THE BOUVEAULT REACTION INTERMEDIATE

Article abstract of DOI:10.1016/S0040-4039(00)84377-4

The Bouveault reaction intermadiate prepared under sonochemical conditions easily undergoes orthodirected lithiation.The use of tetrahydropyran as a solvent dramatically increases the rates and yields of metallation which can be accomplished with an in situ generated alkyl-lithium.