Copper-catalyzed Reaction of Anthranils with Methyl Ketones: Site-Selective C5-Dicarbonylation of Anthranils

Article abstract of DOI:10.1002/adsc.202001334

A copper-catalyzed site-selective C5-dicarbonylation reaction of anthranils has been developed for synthesis of 1,2-dicarbonyl compounds using methyl ketone as a commercially available carbonylation reagent. This process represents the first example to implement the C5-dicarbonylation of anthranils, which involves an oxidative Csp³-H/Csp²-H cross-coupling reaction along with thermolytic N?O bond cleavage. (Figure presented.).