Facile perfluoroalkylation of uracils and uridines at the C-5 position

Article abstract of DOI:10.1016/S0022-1139(00)80396-6

Perfluoroalkylation at the C-5 position of uracil has been achieved in yields of 38-56percent by the reaction of its bis(trimethylsilyl) derivative with bis(perfluoroalkanoyl) peroxides and the hydrolytic deprotection of the silylated products.A substituent or nitrogen replacement at C-6 does not interfere with perfluoroalkylation at C-5, but no significant reaction occurs at C-6 when C-5 is blocked.