Bioorganic and Medicinal Chemistry Letters p. 2425 - 2430 (1999)
Update date:2022-08-17
Topics:
Armer, Richard E.
Barlow, Jacqueline S.
Chopra, Narinder
Dutton, Christopher J.
Greenway, David H.J.
Greenwood, Sean D.W.
Lad, Nita
Shaw, Jonothan
Thompson, Adrian P.
Thong, Kam-Wah
Tommasini, Ivan
Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated. Novel analogues of equal or improved efficacy in vitro and in vivo to pentaquine were discovered.
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