Bulletin of the Chemical Society of Japan p. 2528 - 2531 (1994)
Update date:2022-08-29
Topics:
Jayasinghe, Leonard Y.
Kodituwakku, Devika
Smallridge, Andrew J.
Trewhella, Maurie A.
The reduction of ethyl acetoacetate to ethyl (S)-3-hydroxybutyrate, mediated by freeze-dried yeast, proceeds in good yield (53-58percent) and with high enantioselectivity (>96percentee) in a number of organic solvents; petroleum ether, diethyl ether, toluene, and carbon tetrachloride.A small amount of water (0.8 ml (g-yeast)-1) is required for the reaction to proceed.The water/yeast/substrate ratio and the solvent polarity have been found to significantly influence the reactivity of the system.The enantiomeric excess was determined by gas chromatography employing a chiral column.
View MoreGuangzhou PI & PI Biotech Inc. Ltd.
Contact:+86-20-81716320
Address:Suite 501,198 Kaiyuan Ave.,Science City, Guangzhou,China
Shandong Xiangde Biotechnology Co., Ltd
Contact:+86 -15066639877
Address:Sanba street
website:http://www.alwaychem.com
Contact:+86-532-8586-4000, 8586-5000
Address:NO.51, TAIPING ROAD, QINGDAO, CHINA. 266001
Shandong Ailitong New Material Co.,Ltd
Contact:+86-536-3226266
Address:zhongjia village, putong town , qingzhou city,Shandong Province,China
PharmaResources(Kaiyuan)CO,.Ltd
Contact:+86-21-50720028
Address:No.3, Beihuan Road, Economic Development District, Kaiyuan City, Tieling City, Liaoning Province, China 112300
Doi:10.1002/adsc.201600894
(2017)Doi:10.1016/0039-128X(73)90138-4
(1973)Doi:10.1039/P29860000075
(1986)Doi:10.1016/S0040-4039(02)00879-1
(2002)Doi:10.1002/pola.27794
(2016)Doi:10.1080/00397919808004949
(1998)