L-nucleoside analogues as potential antimalarials that selectively target Plasmodium falciparum adenosine deaminase

Article abstract of DOI:10.1080/07328319908044624

The L-stereoisomer analogues of D-coformycin selectively inhibited P. falciparum adenosine deaminase (ADA) in the picomolar range (L-isocoformycin, K(i) 7 pM; L-coformycin, K(i) 250 pM). While the L-nucleoside analogues, L- adenosine, 2,6-diamino-9-(L-ribofuranosyl)purine and 4-amino- 1 -(L- ribofuranosyl)pyrazolo[3,4-d]-pyrimidine were selectively deaminated by P. falciparum ADA, L-thioinosine and L-thioguanosine were not. This is the first example of 'non-physiological' L-nucleosides that serve as either substrates or inhibitors of malarial ADA and are not utilised by mammalian ADA.

Full text of DOI:10.1080/07328319908044624

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Nucleosides and Nucleotides
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L-Nucleoside Analogues as Potential
Antimalarials That Selectively Target
Plasmodium Falclparum Adenosine
Deaminase
David M. Brown a , Andrew G. Netting a , Byoung K. Chun b ,
Yongseok Choi b , Chung K. Chu b & Annette M. Gero a
a School of Biochemistry and Molecular Genetics , University of New
South Wales , Sydney, NSW 2052, Australia
b College of Pharmacy, The University of Georgia , Athens, Ga,
30602, USA
Published online: 04 Oct 2006.
To cite this article: David M. Brown , Andrew G. Netting , Byoung K. Chun , Yongseok Choi , Chung
K. Chu & Annette M. Gero (1999) L-Nucleoside Analogues as Potential Antimalarials That Selectively
Target Plasmodium Falclparum Adenosine Deaminase, Nucleosides and Nucleotides, 18:11-12,
2521-2532, DOI: 10.1080/07328319908044624
To link to this article: http://dx.doi.org/10.1080/07328319908044624
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