A novel approach to tricyclic pharmaceuticals via directed dilithiation of diaryl compounds

DOI: 10.1016/0040-4039(96)01068-4

Source and publish data:

Tetrahedron Letters p. 5073 - 5076 (1996)

Update date:2022-08-23

Topics:

Authors:

Birman, Vladimir B.

Chopra, Anu

Ogle, Craig A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(96)01068-4

Tricyclic compounds were prepared using a novel approach based on the reaction between dilithio-diphenyl ether with appropriately substituted esters. The pharmaceutical drag, clopipazan, and its corresponding deschloro analog were synthesized utilizing this approach.

Full text of DOI:10.1016/0040-4039(96)01068-4

Products guided by the article

Product name:Clopipazan

Cas No:60085-78-1

R&D Labs maybe for 60085-78-1

Chengdu ZY Biochemical Technology Co., LTD

Contact:0086-28-88680086

Address:170 Qingpu Road, Shouan Town, Pujiang County
Suzhou JMS Chemical Co., Ltd.

Contact:+86-15995924277

Address:WuZhongOu suzhou new south road 89
Xi'an Unique Electronic and Chemical Co., Ltd.

Contact:+86-029-88238008

Address:1703# B BUILDING WEST ELECTRONIC ZONE, XI'AN, CHINA
Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Hebei Fulong Import & Export Co., Ltd.

Contact:86-311-87795661

Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China

Relevant to this article

Selective Isomerization of 1,2-Epoxyalkanes to Aldehydes with Lithium Dialkylamides

Doi:10.1039/c39940002103
(1994)
Powder ENDOR Spectra of p-Benzoquinone Anion Radical: Principal Hyperfine Tensor Components for Ring Protons and for Hydrogen-Bonded Protons

Doi:10.1021/ja00274a024
(1986)
Doi:10.1016/S0022-328X(00)84543-X
(1979)
Polycyclic N-heterocyclic compounds. Part 84: Reaction of N-(pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-yl)amidines or N-(pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-yl)amidines with hydroxylamine hydrochloride

Doi:10.1002/jhet.2033
(2015)
Design Principles for Trap-Free CsPbX₃ Nanocrystals: Enumerating and Eliminating Surface Halide Vacancies with Softer Lewis Bases

Doi:10.1021/jacs.8b11035
(2018)
First-and second-generation heterometallic dendrimers containing ferrocenyl-ruthenium(II)-arene motifs: Synthesis, structure, electrochemistry, and preliminary cell proliferation studies

Doi:10.1021/om500809g
(2014)

Article Doi