A novel approach to tricyclic pharmaceuticals via directed dilithiation of diaryl compounds

DOI: 10.1016/0040-4039(96)01068-4

Source and publish data:

Tetrahedron Letters p. 5073 - 5076 (1996)

Update date:2022-08-23

Topics:

Authors:

Birman, Vladimir B.

Chopra, Anu

Ogle, Craig A.

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Article abstract of DOI:10.1016/0040-4039(96)01068-4

Tricyclic compounds were prepared using a novel approach based on the reaction between dilithio-diphenyl ether with appropriately substituted esters. The pharmaceutical drag, clopipazan, and its corresponding deschloro analog were synthesized utilizing this approach.

Full text of DOI:10.1016/0040-4039(96)01068-4

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Product name:Clopipazan

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