Unsaturated acyclic analogues of 2'-deoxyadenosine and thymidine containing fluorine: Synthesis and biological activity

Article abstract of DOI:10.1021/jm00006a004

The syntheses and biological activities of fluorobutynol 11 and (E)- and (Z)-fluorobutenols 8a,d and 9a,d are described. Alkylation of adenine with bromofluorobutyne 13a afforded intermediate 14 which was converted to fluorobutynol 11. Aldehyde 16a and (c