4-Cyanothiazolidides as very potent, stable inhibitors of dipeptidyl peptidase IV

Article abstract of DOI:10.1016/S0960-894X(96)00491-X

A series of stable, very potent inhibitors of dipeptidyl peptidase IV has been developed. A number of dipeptide analogues, incorporating a 4-cyanothiazolidide, were found to have K(i) values of less than 1 nM versus human DP-IV and half-lives of between 5 and 27h in aqueous solution (pH 7.4).