Bioorganic and Medicinal Chemistry Letters p. 2745 - 2748 (1996)
Update date:2022-08-17
Topics:
Ashworth, Doreen M.
Atrash, Butrus
Baker, Graham R.
Baxter, Andrew J.
Jenkins, Paul D.
Jones, D. Michael
Szelke, Michael
A series of stable, very potent inhibitors of dipeptidyl peptidase IV has been developed. A number of dipeptide analogues, incorporating a 4-cyanothiazolidide, were found to have K(i) values of less than 1 nM versus human DP-IV and half-lives of between 5 and 27h in aqueous solution (pH 7.4).
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