The biosynthesis of the mould metabolites roquefortine and aszonalenin from L-[2,4,5,6,7-2H5]tryptophan

Article abstract of DOI:10.1016/S0040-4020(01)81556-8

L-[2,4,5,6,7-²H₅]Tryptophan was incorporated into roquefortine 2 by Penicillium roqueforti and aszonalenin 3 by Aspergillus zonatus with retention in each case of five deuterium atoms; the 5a-hydrogen of both metabolites is derived from the 2-hydrogen of tryptophan.