Diastereoselective formation of α-aminoamides from carbamoylsilanes and aldehyde imines

Article abstract of DOI:10.1016/j.tetasy.2005.01.025

Diastereoselectivities were determined for the reaction of a series of aldehyde imines with carbamoylsilanes, each containing chiral auxiliaries at nitrogen. A maximum de of 88% was achieved via a matched double differentiation.