Green Chemistry p. 4339 - 4348 (2018)
Update date:2022-08-11
Topics:
Zhang, Zhibo
Muschiol, Jan
Huang, Yuhong
Sigurdardóttir, Sigyn Bj?rk
Von Solms, Nicolas
Daugaard, Anders E.
Wei, Jiang
Luo, Jianquan
Xu, Bao-Hua
Zhang, Suojiang
Pinelo, Manuel
Low yields commonly obtained during enzymatic conversion of CO2 to methanol are attributed to low CO2 solubility in water. In this study, four selected ionic liquids with high CO2 solubility were separately added to the multi-enzyme reaction mixture and the yields were compared to the pure aqueous system (control). In an aqueous 20% [CH][Glu] system, yield increased ca. 3.5-fold compared to the control (ca. 5-fold if NADH regeneration was incorporated). Molecular dynamics simulation revealed that CO2 remains for longer in a productive conformation in the enzyme in the presence of [CH][Glu], which explains the marked increase of yield that was also confirmed by isothermal titration calorimetry-lower energy (ΔG) binding of CO2 to FDH. The results suggest that the accessibility of CO2 to the enzyme active site depends on the absence/presence and nature of the ionic liquid, and that the enzyme conformation determines CO2 retention and hence final conversion.
View MoreSuqian Ruixing Chemical Co., Ltd.
Contact:+86-527-80805666(总机);84836008(销售)
Address:3 Jingsilu, Zone north, Hubin Xincheng Development Park, Suqian, China
Weifang Arylchem Chemical Co., LTD
Contact:86-536-5217866
Address:Development Zone, Shouguang, Shandong Province
SHANDONG QINGYUNCHANGXIN CHEMICAL SCIENCE-TECH CO.,LTD
Contact:86-21-60560171
Address:1689Donghuan Rade,Qingyun County, Dezhou City, Shandong,China
Contact:+86-571-86025531 / 86024803
Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Nanjing distinctions Medical Technology Co., Ltd.
Contact:+86-15996203785 13914714059
Address:nanjing,jiangsu , China
Doi:10.1021/acscatal.7b04084
(2018)Doi:10.1016/S0040-4020(01)96678-5
(1985)Doi:10.1016/j.tet.2015.05.103
(2016)Doi:10.1039/d0dt01553a
(2020)Doi:10.1021/ja01355a003
(1931)Doi:10.1002/adsc.201600840
(2016)