A new approach to isoindolobenzazepines via a ring-expansion of isoindoloisoquinoline: Synthesis of lennoxamine and chilenine

Article abstract of DOI:10.1016/S0040-4039(99)00140-9

A convenient short-step synthesis of lennoxamine 1 and chilenine 2 is described. The key steps are the preparation of an acyliminium precursor and a novel expansion of the six-membered ring to a seven-membered ring.