A new approach to isoindolobenzazepines via a ring-expansion of isoindoloisoquinoline: Synthesis of lennoxamine and chilenine

DOI: 10.1016/S0040-4039(99)00140-9

Source and publish data:

Tetrahedron Letters p. 2169 - 2172 (1999)

Update date:2022-08-23

Topics:

Authors:

Koseki, Yuji

Kusano, Shuichi

Sakata, Harumi

Nagasaka, Tatsuo

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Article abstract of DOI:10.1016/S0040-4039(99)00140-9

A convenient short-step synthesis of lennoxamine 1 and chilenine 2 is described. The key steps are the preparation of an acyliminium precursor and a novel expansion of the six-membered ring to a seven-membered ring.

Full text of DOI:10.1016/S0040-4039(99)00140-9

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