Strictly regio- and stereo-controlled α-alkenylation of bicyclic enone derivatives via palladium-catalyzed cross coupling and its application to a formal synthesis of (±)-carbacyclin

Article abstract of DOI:10.1016/S0040-4020(98)00347-0

A formal synthesis of carbacylin was achieved by preparing a known advanced intermediate 15 via Zr-promoted enyne bicyclization-carbonylation, Pd-catalyzed α-alkenylation of bicyclic enones, and conjugate reduction.