Selective Oxidation of 2-Methylnaphthalene to 2-Methyl-1-naphthol by Rhodococcus sp. M192

Article abstract of DOI:10.1271/bbb.60.769

About 6000 isolates of microorganisms assimilating methylketones (C₃-C₆) were tested for their selective oxidation of 2-methylnaphthalene to 2-methyl-1-naphthol. Strain M192 was the highest 2-methyl-1-naphthol producer and was classified as the genus Rhodococcus. The optimal conditions for the site-specific oxidation were studied using resting Rhodococcus sp. M192. The 2-methyl-1-naphthol productivity was specifically increased using methylethylketone as a carbon source, 1-propanol as a solvent to dissolve the substrate, and ethylxanthate or diethyldithiocarbamate as an inhibitor of 2-naphthoic acid (side-product) production. In the presence of these compounds, 2-methylnaphthalene was specifically oxidized at the 1-position without the conversion to 2-naphthoic acid. The productivity of 2-methyl-1-naphthol was about 90 μM from 1 mM 2-methylnaphthalene.

Full text of DOI:10.1271/bbb.60.769

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Selective Oxidation of 2-Methylnaphthalene to 2-
Methyl-l-naphthol by Rhodococcus sp. M192
Hisataka Taguchia, Shunbun Kitaa, Motoo Kobayashia & Yoshiki Tana
a Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Sakyo-
ku, Kyoto 606–01, Japan
Published online: 12 Jun 2014.
To cite this article: Hisataka Taguchi, Shunbun Kita, Motoo Kobayashi & Yoshiki Tan (1996) Selective Oxidation of 2-
Methylnaphthalene to 2-Methyl-l-naphthol by Rhodococcus sp. M192, Bioscience, Biotechnology, and Biochemistry, 60:5,
769-772, DOI: 10.1271/bbb.60.769
To link to this article: http://dx.doi.org/10.1271/bbb.60.769
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