Synthesis of (Z)-ligustilide

Article abstract of DOI:10.1080/00397919308012612

The first synthesis of ligustilide (1) is described, starting from 2-formylbenzoic acid (2). The key step in synthesis is the Birch reduction of 3-hydroxybutyl-phthalide (4).

Full text of DOI:10.1080/00397919308012612

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Synthesis of (Z)-Ligustilide
a b
a
a
Shaobai Li , Zhiwei Wang , Xiaoping Fang
&
a
Yulin Li
a
State Key Laboratory of Applied Organic Chemistry
and Institute of Organic Chemistry, Lanzhou
University, Lanzhou, 730000
b
Department of Chemistry, Huizhou Normal College
Version of record first published: 23 Sep 2006.
To cite this article: Shaobai Li , Zhiwei Wang , Xiaoping Fang & Yulin Li (1993):
Synthesis of (Z)-Ligustilide, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 23:20, 2909-2913
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