Synthesis of Bis(α-amino acids) by Palladium-catalyzed Allylic Double Substitution

Article abstract of DOI:10.1016/0040-4039(95)01574-2

The reaction of lithium enolate derived from benzophenone imine of glycine ethyl ester 1 with allylic dihalides 2 in the presence of a catalytic amount of Pd(PPh3)4 (5percent mol) affords the corresponding bis(imino esters) 3.Subsequent hydrolysis of comp