Mendeleev Commun., 2017, 27, 134–136
Table 1 Antimicrobial and hemolytic activity of compounds 4, 5 and 7.
Minimum inhibitory concentration/mg ml–1
Bacteriostatic and fungistatic activity Bactericidal and fungicidal activity
Bc Ec Pa An Tm Bc Ec Pa An Tm
125 125 >500 >500 >500 >500 >500
Hemolytic activity
Compound
Concentration/ Hemolysis
mg ml–1
(%)
Sa
Ca
Sa
Ca
4
5
7
125 >500 >500 >500 >500 >500 >500
15.6 >500 >500 >500 >500 125 >500
15.6 500 500 500 500 125 250
250 62.5 >500 >500 >500 >500 >500 >500 >500 >500 >500 >500 >500 >500
15.6
0.1
Chloramphenicol 62.5
Ketoconazole
2.5
25
3.9
3.9
on the reaction of 1,4naphthoquinones with P–H phosphonium
salts. The reaction occurs under mild conditions and provides high
yields of the target compounds.
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and I. A. Litvinov, Mendeleev Commun., 2011, 21, 346; (b) N. R.
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This work was supported by the Russian Science Foundation
(Zh. Org. Khim., 2015, 51, 1369); (c)V. F. Mironov, N. R. Khasiyatullina
(grant no. 145000014).
and D. B. Krivolapov, Tetrahedron Lett., 2015, 56, 7132.
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Online Supplementary Materials
Supplementary data associated with this article can be found
in the online version at doi:10.1016/j.mencom.2017.03.008.
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Received: 5th September 2016; Com. 16/5039
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