Intramolecular Amidoalkylation of Chiral Imines and Iminium Ions: Stereoselective Synthesis of anti-1,2- and -1,3-Aminoalcohols

Article abstract of DOI:10.1016/0040-4039(95)00286-7

When treated with Lewis acids, 2- or 3-vinyl- or -phenylsiloxyaminoacetals generated the corresponding imines or iminium ions which in turn underwent smooth intramolecular amidoalkylation to afford anti-1,2- or -1,3-aminoalcohol derivatives in very high c