Tetrahedron Letters p. 513 - 516 (1995)
Update date:2022-08-25
Topics:
Wang, Steven S.
Shi, Xiao-Xin
Powell, William S.
Tieman, Tamara
Feinmark, Steven J.
Rokach, Joshua
The first total synthesis of the 10,11-dihydro-12-ketoeicosaretraenoic acid (10,11-dihydro-12-KETE) 5, a proinflammatory metabolite of 12-KETE is reported. In addition, the total synthesis of two other potential metabolites of 12-KETE, namely 8,11-dihydro-12-KETE 6 and 8,9-dihydro 12-KETE 7, is also described. These three synthetic compounds are aimed at investigating a new biosynthetic reductive pathway for 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-KETE.
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