Chemical and Pharmaceutical Bulletin p. 537 - 546 (1995)
Update date:2022-08-11
Topics:
Laatsch
Renneberg
Hanefeld
Kellner
Pudleiner
Hamprecht
Kraemer
Anke
Antitumor, antimicrobial, and phytotoxic activities of the marine antibiotic pentabromopseudilin (la) and related phenyl-, benzyl- and benzoyl pyrroles were compared. All activities depended strongly on the substituent pattern, with the natural compound 1a being the most active one. As judged from model reactions, a covalent bond of nucleophiles to the pyrrole system may be involved in the inhibition of macromolecular syntheses.
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(1947)
