ALKENYL-COPPER DERIVATIVES 24 STEREOSPECIFIC SYNTHESIS OF ENONES BY PALLADIUM CATALYSED ACYLATION OF ALKENYL-COPPER REAGENTS

Article abstract of DOI:10.1016/S0040-4039(00)94046-2

α,β-ethylenic ketones and α,α',β,β'diethylenic ketones with a stereodefined substitution pattern are easily prepared by coupling of alkenyl copper and cuprate reagents, directly obtained by carbocupration of alkynes, with acid chlorides and anhydrides in the presence of a catalytic amount of Pd(0) complex.