Dramatic Effect of Substituents and TMEDA Additive on the Regioselectivity of Directed Orthometalation of Tetrasubstituted Aromatics

DOI: 10.1016/0040-4039(94)85064-X

Source and publish data:

Tetrahedron Letters p. 401 - 404 (1994)

Update date:2022-08-10

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Authors:

Khaldi, M.

Chretien, F.

Chapleur, Y.

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Article abstract of DOI:10.1016/0040-4039(94)85064-X

The regioselectivity of the directed orthometalation of tetrasubstituted aromatic N,N-diethylamides was found to depend of the ring substituents and of the base used. a dramatic effect of the additive TMEDA to s-butyllithium has been observed which could

Full text of DOI:10.1016/0040-4039(94)85064-X

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