Synthesis study of 3′-α-fluoro-2′,3′- dideoxyguanosine

Article abstract of DOI:10.1081/NCN-200060053

A synthetic method was established for 3′-α-fluoro-2′, 3′-dideoxyguanosine 1 from guanosine 2 in 27% overall yield and 6 steps. A byproduct 6a of fluorination was identified by NMR studies, its presence strongly supporting our supposition that the fluorination itself proceeded via a bromonium cation. Copyright Taylor & Francis, Inc.