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Cell-to-cell contact and extracellular matrix
Web alert
Jonathon Pines* and Frank Lafont†
A selection of World Wide Web sites relevant to papers
published in this issue of Current Opinion in Cell Biology.
project at Oregon Health and Science University and is of
primary interest to clinical researchers.
Addresses
Presenilin
*Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR;
†University of Geneva, Sciences II, 30 Quai Ernest-Ansermet 1211
Geneva 4, Switzerland. e-mail: frank.lafont@biochem.unige.ch.
Presenilin mutation directory
index.html
The presenilin mutations directory is part of the Alzheimers
research forum. This site is a useful entry point for understanding
the role of presenilin in Alzheimers disease, and it includes maps
of the major mutation sites and an extensive literature review.
Current Opinion in Cell Biology 2001, 13:523–524
Cell-to-cell contact signalling
Armadillo movie
This page is from M Peifer’s laboratory at the University of North
Carolina, Chapel Hill. A movie (Quicktime format) can be down-
loaded that shows the distribution of a GFP–Armadillo chimera
(and thus cell–cell adherens junctions) during the dorsal
closure of the Drosophila embryo.
Presenilin1 at the HotMolecBase
A web page devoted to presenilin. It is part of the HotMolec
database at the Weizmann Institute in Israel. It is a useful site
bringing together links for presenilin from a variety of databases.
The categories of the links are: structure; post-translational
modifications; expression; cellular functions; metabolism;
involvement in diseases; monoclonal antibodies; purification;
manipulation of animal models; open questions; contacting
researchers; and web resources and references. The drawback
to this site is that it does not appear to be regularly updated.
Armadillo alignment
_col.html
This page shows the alignment of Armadillo/β-catenin-like
repeats as compiled by the Homologous Structure Alignment
Database (HOMSTRAD).
Wnt homepage
Angiogenesis
This page is from R Nusse’s website (at Howard Hughes
Medical Center, Stanford). A table lists the Drosophila and
C. elegans Frizzled (Fz) proteins, with links to their sequence
and to proteins that interact with Wnt, as well as listing links
to some literature. Similarly, a vertebrate table is provided
sequence alignment of the different Fz family members can be
fzalign.html.
Angiogenesis movies
A collection of movies from the Department of Medical
Physiology at Texas A&M University illustrating various aspects
of angiogenesis in vitro and lymphatic vessel contractions.
Angiogenesis Project
This page hosts the special project on angiogenesis supported by
the University of Brescia, Italy. A comprehensive site on angio-
genesis. This site has an outline of angiogenesis, information on its
clinical relevance as well as a description of what is known of its
biochemistry and cell biology. The site is searchable and has a
number of links to a variety of other relevant sites and resources
incuding Quicktime movies of vascularisation in vivo and in vitro.
Ed Bowder’s movies page
This page (from E Bowder’s website) by M Krendel shows a
movie (in Avi format) of actin reorganization upon epithelial
cell-to-cell contact.
Integrins
The Integrin Page
Cell migration
Granulocytes migration
A classic, very useful platform where you can find the
answer to everything you want to know on integrins available
of the net.
A collection of light and electron microscopy images and
movies showing, for example, granulocytes undergoing
chemoattraction and various acts of phagocytosis.
Leukocyte migration
Matrix metalloproteinases
Metalloproteinase at Cliniweb
index.html
A site bringing together the OMIM and PubMed entries for
metalloproteinases. It is part of the CliniWeb International
A very useful site illustrating the leukocyte adhesion cascade in
the inflammation response. Each stage is illustrated with links to
descriptions of the molecules involved.
Winterfeld
