Bioorganic and Medicinal Chemistry Letters p. 2379 - 2384 (1999)
Update date:2022-08-25
Topics:
James, David A.
Swamy, Narasimha
Paz, Nancy
Hanson, Robert N.
Ray, Rahul
A tetraphenylporphyrin-C11-β-estradiol conjugate has been synthesized. Competitive binding assay of the conjugate with estrogen receptor (ER)-ligand-binding domain showed that the conjugate binds specifically to the protein with high affinity. Potential use of this conjugate to selectively deliver cytotoxic porphyrins to ER-positive cells in various carcinomas is discussed.
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