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Glycine

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Name

Glycine

EINECS 200-272-2
CAS No. 56-40-6 Density 1.254 g/cm3
Solubility 25 g/100 mL (25 °C) in water Melting Point 240 °C (dec.)(lit.)
Formula C2H5NO2 Boiling Point 240.937 °C at 760 mmHg
Molecular Weight 75.07 Flash Point 99.516 °C
Transport Information Appearance White crystalline powder
Safety 22-24/25 Risk Codes 33
Molecular Structure Molecular Structure of 56-40-6 (Glycine) Hazard Symbols
Synonyms

L-Glycine;FEMA No. 3287;Leimzucker;aminoacetic acid;Glicoamin;Padil;Gly;Glyzin;Glycolixir;Glycosthene;2-Aminoacetic acid;Glycine (JP14/USP);Glycin;Amitone;Glycocoll;Glycine food grade;Aminoacetic acid(Glycine);H-Gly-OH (Physic Grade);H-Gly-OH;

 

Glycine Standards and Recommendations

In the USA, glycine is typically sold in two grades: USP ("United States Pharmacopeia"), and technical grade.the two grades have diverse uses.
Pharmaceutical grade Glycine (CAS NO.56-40-6) is use in some pharmaceutical applications, such as intravenous injections, where the customer's purity requirements often exceed the minimum required under the USP grade designation.
Technical grade glycine, which may or may not meet USP grade standards, often use in industrial applications; such as an agent in metal complexing and finishing.

Glycine Specification

1. Introduction of Glycine

Glycine, with the IUPAC Name of 2-Aminoacetic acid, is one kind of white crystalline powder. This chemical belongs to the Classification Code which include Component of irrigating solution; Glycine Agents; Mutation data; Neurotransmitter Agents.

2. Properties of Glycine

Glycine has the following property datas: (1)Melting point: 240 °C; (2)Index of Refraction: 1.46; (3)Molar Refractivity: 16.41 cm3; (4)Molar Volume: 59.8 cm3; (5)Surface Tension: 54.4 dyne/cm; (6)Density: 1.254 g/cm3; (7)Flash Point: 99.5 °C; (8)Enthalpy of Vaporization: 52.63 kJ/mol; (9)Boiling Point: 240.9 °C at 760 mmHg; (10)Vapour Pressure: 0.0123 mmHg at 25°C.

3. Structure Descriptors of Glycine

You could convert the following datas into the molecular structure:
InChI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) 
InChIKey: InChIKey=DHMQDGOQFOQNFH-UHFFFAOYSA-N 
Smiles: C(=O)(CN)O

4. Uses of Glycine

Glycine has many uesage:
1).Animal and human foodstuffs:
use an additive in pet food and animal feed. For humans, glycine is used as a sweetener/taste enhancer. such as Food supplements and protein drinks.some drug formulations use glycine to improve gastric absorption.
2).Chemical feedstock
Glycine is an intermediate in the synthesis of a variety of chemical products. It is used in the manufacture of the herbicide Glyphosate. Glyphosate (N-(phosphonomethyl) glycine) is a non-selective systemic herbicide used to kill weeds, especially perennials and broadcast or used in the cut-stump treatment as a forestry herbicide. Initially, Glyphosate was sold only by Monsanto under the Monsanto tradename Roundup, but is no longer under patent
3).Cosmetics and other applications:
Glycine can be used  as a buffering agent in  analgesics, antacids, cosmetics, antiperspirants, and toiletries.Many products use glycine or its derivatives, such as the production of rubber sponge products, fertilizers, metal complexants.

5. Safety information of Glycine

Risk Statements of Glycine (CAS NO.56-40-6): 33 
R33: Danger of cumulative effects.
Safety Statements: 22-24/25
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes.

6. Production of Glycine

Glycine (CAS NO.56-40-6)e is manufactured  by treating chloroacetic acid with ammonia industrially
ClCH2COOH + 2 NH3 → H2NCH2COOH + NH4Cl
It also can be  produced via the Strecker amino acid synthesis.

7. Toxicity information of Glycine

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 3gm/kg (3000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 31, Pg. 306, 1942.
mouse LD50 intraperitoneal 4450mg/kg (4450mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
mouse LD50 intravenous 2370mg/kg (2370mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
mouse LD50 oral 4920mg/kg (4920mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
mouse LD50 subcutaneous 5060mg/kg (5060mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
rat LD50 intravenous 2600mg/kg (2600mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
rat LD50 oral 7930mg/kg (7930mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
rat LD50 subcutaneous 5200mg/kg (5200mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.

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