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Name |
Hydralazine hydrochloride |
EINECS | 206-151-0 |
CAS No. | 304-20-1 | Density | 1.2961 (rough estimate) |
PSA | 63.10000 | LogP | 1.72400 |
Solubility | Soluble in water. Slightly soluble in diethyl ether and alcohol. | Melting Point |
273 °C |
Formula | C8H9ClN4 | Boiling Point | 491.9 °C at 760 mmHg |
Molecular Weight | 196.639 | Flash Point | 251.3 °C |
Transport Information | UN 2811 6.1/PG 3 | Appearance | white crystalline solid |
Safety | 26-36/37/39-45 | Risk Codes | 22-36/37/38 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
1(2H)-Phthalazinone,hydrazone, monohydrochloride (9CI);Phthalazine, 1-hydrazino-,monohydrochloride (8CI);(Phthalazin-1-yl)hydrazine hydrochloride;1-Hydrazinophthalazine hydrochloride;1-Hydrazinophthalazine monohydrochloride;Apresoline hydrochloride;Apulon;Hydralazine chloride;Hydralazine monohydrochloride;Lopres;Hydralazine hcl; |
Article Data | 6 |
Conditions | Yield |
---|---|
Stage #1: phthalazone With trichlorophosphate at 75℃; for 0.5h; Stage #2: With hydrazine hydrate In ethanol; water at 60 - 70℃; for 2h; Stage #3: With hydrogenchloride In ethanol; water pH=3; | 65% |
1-hydrazinophthalazine
hydralazine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water at 70 - 80℃; Product distribution / selectivity; | 80% |
With hydrogenchloride In water at 70 - 80℃; Product distribution / selectivity; | 80% |
With hydrogenchloride In water at 70 - 80℃; for 0.25h; Product distribution / selectivity; | 65% |
With hydrogenchloride Product distribution / selectivity; |
2-formylphenyl tosylate
hydralazine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate; palladium(II) trifluoroacetate; 1,3-bis-(diphenylphosphino)propane; magnesium sulfate; t-butoxycarbonylhydrazine / acetonitrile / 21 h / 140 °C / 7500.75 Torr / Autoclave 2.1: trichlorophosphate / 0.5 h / 75 °C 2.2: 2 h / 60 - 70 °C 2.3: pH 3 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile; water / 2 h / 20 °C 2.1: potassium carbonate; palladium(II) trifluoroacetate; 1,3-bis-(diphenylphosphino)propane; magnesium sulfate; t-butoxycarbonylhydrazine / acetonitrile / 21 h / 140 °C / 7500.75 Torr / Autoclave 3.1: trichlorophosphate / 0.5 h / 75 °C 3.2: 2 h / 60 - 70 °C 3.3: pH 3 View Scheme |
phthalazin-1-ylamine
hydralazine hydrochloride
Conditions | Yield |
---|---|
Stage #1: phthalazin-1-ylamine With hydrogenchloride; sodium nitrite at -5℃; Stage #2: With tin(ll) chloride; sodium sulfite |
IARC Cancer Review: Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 , 1980,p. 85.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.
This chemical is called Hydralazine hydrochloride, and its IUPAC name is phthalazin-1-ylhydrazine hydrochloride. With the molecular formula of C8H9ClN4, its classification codes are Antihypertensive; Drug / Therapeutic Agent; Mutation data; Reproductive Effect; Tumor data. The CAS registry number of this chemical is 304-20-1. Additionally, its product categories are Chemical Amines; Amines; Aromatics; Heterocycles; Inhibitors; Monoamine Oxidase. It's a direct-acting vasodilator that is used as an antihypertensive agent.
Other characteristics of the Hydralazine hydrochloride can be summarised as followings: (1)ACD/LogP: 1.00; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.54; (4)ACD/LogD (pH 7.4): 0.99; (5)ACD/BCF (pH 5.5): 1.17; (6)ACD/BCF (pH 7.4): 3.31; (7)ACD/KOC (pH 5.5): 28.69; (8)ACD/KOC (pH 7.4): 81.4; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 32.26 Å2; (13)Flash Point: 251.3 °C; (14)Enthalpy of Vaporization: 75.87 kJ/mol; (15)Boiling Point: 491.9 °C at 760 mmHg; (16)Vapour Pressure: 8.05E-10 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1.SMILES: Cl.n2nc(c1ccccc1c2)NN
2.InChI: InChI=1/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
3.InChIKey: ZUXNZUWOTSUBMN-UHFFFAOYAU
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 83mg/kg (83mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 368, 1951. | |
mouse | LD50 | intravenous | 71mg/kg (71mg/kg) | Drugs in Japan Vol. -, Pg. 1006, 1995. | |
mouse | LD50 | oral | 188mg/kg (188mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 97, 1969. | |
mouse | LD50 | subcutaneous | 73mg/kg (73mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Sapporo Igaku Zasshi. Sapporo Medical Journal. Vol. 6, Pg. 362, 1954. |
rat | LD50 | intravenous | 34mg/kg (34mg/kg) | Drugs in Japan Vol. 6, Pg. 619, 1982. | |
rat | LD50 | oral | 280mg/kg (280mg/kg) | Drugs in Japan Vol. -, Pg. 1006, 1995. |