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Hydralazine hydrochloride

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Name

Hydralazine hydrochloride

EINECS 206-151-0
CAS No. 304-20-1 Density 1.2961 (rough estimate)
PSA 63.10000 LogP 1.72400
Solubility Soluble in water. Slightly soluble in diethyl ether and alcohol. Melting Point 273 °C
Formula C8H9ClN4 Boiling Point 491.9 °C at 760 mmHg
Molecular Weight 196.639 Flash Point 251.3 °C
Transport Information UN 2811 6.1/PG 3 Appearance white crystalline solid
Safety 26-36/37/39-45 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 304-20-1 (Hydralazine hydrochloride) Hazard Symbols HarmfulXn
Synonyms

1(2H)-Phthalazinone,hydrazone, monohydrochloride (9CI);Phthalazine, 1-hydrazino-,monohydrochloride (8CI);(Phthalazin-1-yl)hydrazine hydrochloride;1-Hydrazinophthalazine hydrochloride;1-Hydrazinophthalazine monohydrochloride;Apresoline hydrochloride;Apulon;Hydralazine chloride;Hydralazine monohydrochloride;Lopres;Hydralazine hcl;

Article Data 6

Hydralazine hydrochloride Synthetic route

119-39-1

phthalazone

304-20-1

hydralazine hydrochloride

Conditions
ConditionsYield
Stage #1: phthalazone With trichlorophosphate at 75℃; for 0.5h;
Stage #2: With hydrazine hydrate In ethanol; water at 60 - 70℃; for 2h;
Stage #3: With hydrogenchloride In ethanol; water pH=3;
65%
1044569-46-1

1-hydrazinophthalazine

304-20-1

hydralazine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 70 - 80℃; Product distribution / selectivity;80%
With hydrogenchloride In water at 70 - 80℃; Product distribution / selectivity;80%
With hydrogenchloride In water at 70 - 80℃; for 0.25h; Product distribution / selectivity;65%
With hydrogenchloride Product distribution / selectivity;
19820-56-5

2-formylphenyl tosylate

304-20-1

hydralazine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate; palladium(II) trifluoroacetate; 1,3-bis-(diphenylphosphino)propane; magnesium sulfate; t-butoxycarbonylhydrazine / acetonitrile / 21 h / 140 °C / 7500.75 Torr / Autoclave
2.1: trichlorophosphate / 0.5 h / 75 °C
2.2: 2 h / 60 - 70 °C
2.3: pH 3
View Scheme
90-02-8

salicylaldehyde

304-20-1

hydralazine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile; water / 2 h / 20 °C
2.1: potassium carbonate; palladium(II) trifluoroacetate; 1,3-bis-(diphenylphosphino)propane; magnesium sulfate; t-butoxycarbonylhydrazine / acetonitrile / 21 h / 140 °C / 7500.75 Torr / Autoclave
3.1: trichlorophosphate / 0.5 h / 75 °C
3.2: 2 h / 60 - 70 °C
3.3: pH 3
View Scheme
19064-69-8

phthalazin-1-ylamine

304-20-1

hydralazine hydrochloride

Conditions
ConditionsYield
Stage #1: phthalazin-1-ylamine With hydrogenchloride; sodium nitrite at -5℃;
Stage #2: With tin(ll) chloride; sodium sulfite

Hydralazine hydrochloride Consensus Reports

IARC Cancer Review: Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 , 1980,p. 85.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.

Hydralazine hydrochloride Specification

This chemical is called Hydralazine hydrochloride, and its IUPAC name is phthalazin-1-ylhydrazine hydrochloride. With the molecular formula of C8H9ClN4, its classification codes are Antihypertensive; Drug / Therapeutic Agent; Mutation data; Reproductive Effect; Tumor data. The CAS registry number of this chemical is 304-20-1. Additionally, its product categories are Chemical Amines; Amines; Aromatics; Heterocycles; Inhibitors; Monoamine Oxidase. It's a direct-acting vasodilator that is used as an antihypertensive agent. 

Other characteristics of the Hydralazine hydrochloride can be summarised as followings: (1)ACD/LogP: 1.00; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.54; (4)ACD/LogD (pH 7.4): 0.99; (5)ACD/BCF (pH 5.5): 1.17; (6)ACD/BCF (pH 7.4): 3.31; (7)ACD/KOC (pH 5.5): 28.69; (8)ACD/KOC (pH 7.4): 81.4; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 32.26 Å2; (13)Flash Point: 251.3 °C; (14)Enthalpy of Vaporization: 75.87 kJ/mol; (15)Boiling Point: 491.9 °C at 760 mmHg; (16)Vapour Pressure: 8.05E-10 mmHg at 25°C. 

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure: 
1.SMILES: Cl.n2nc(c1ccccc1c2)NN
2.InChI: InChI=1/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
3.InChIKey: ZUXNZUWOTSUBMN-UHFFFAOYAU

The toxicity data is as follows: 
 

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 83mg/kg (83mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 368, 1951.
mouse LD50 intravenous 71mg/kg (71mg/kg)   Drugs in Japan Vol. -, Pg. 1006, 1995.
mouse LD50 oral 188mg/kg (188mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 97, 1969.
mouse LD50 subcutaneous 73mg/kg (73mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Sapporo Igaku Zasshi. Sapporo Medical Journal. Vol. 6, Pg. 362, 1954.
rat LD50 intravenous 34mg/kg (34mg/kg)   Drugs in Japan Vol. 6, Pg. 619, 1982.
rat LD50 oral 280mg/kg (280mg/kg)   Drugs in Japan Vol. -, Pg. 1006, 1995.

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