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| CAS No.: | 7531-52-4 |
|---|---|
| Name: | L-Prolinamide |
| Molecular Structure: | |
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|
|
| Formula: | C5H10N2O |
| Molecular Weight: | 114.147 |
| Synonyms: | Prolinamide;(2S)-pyrrolidine-2-carboxamide;H-Pro-NH2;(2S)-2,3,4,5-tetrahydropyrrole-2-carboxamide;(S)-Prolinamide;Pro-NH2;Pro- NH2;L-Prolinmide; |
| EINECS: | 231-397-0 |
| Density: | 1.106 g/cm3 |
| Melting Point: | 97-102 °C |
| Boiling Point: | 303.6 °C at 760 mmHg |
| Flash Point: | 137.4 °C |
| Solubility: | Soluble in water and ethanol (50 mg/ml). |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22-36/37/38 |
| Safety: | 22-24/25-36/37/39-26 |
| PSA: | 55.12000 |
| LogP: | 0.25280 |
Z-Pro-NH2
L-prolinamide
| Conditions | Yield |
|---|---|
| With 10% palladium on carbon; hydrogen In methanol for 7h; | 100% |
| With hydrogen; palladium on activated charcoal In methanol for 9h; Ambient temperature; | 88.4% |
| With hydrogen; palladium on activated charcoal In methanol under 2068.6 Torr; for 5h; | 87% |
| With hydrogen; palladium In methanol for 3h; |
N-acetyl-L-prolinamide
L-prolinamide
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 103℃; for 2h; Temperature; | 95.3% |
| Conditions | Yield |
|---|---|
| With ammonia In methanol | 91% |
| With ammonia In methanol at 0 - 20℃; for 15h; Reagent/catalyst; Large scale; | 85% |
| With ammonia In methanol at -25℃; for 96h; Sealed tube; | 55% |
| Conditions | Yield |
|---|---|
| With ammonia In methanol at 65℃; for 15h; | 90% |
| With methanol; ammonia | |
| With ammonium hydroxide | |
| With ammonium hydroxide In butan-1-ol at 5 - 30℃; |
(2S,1'S)-1-(1'-phenylethyl)pyrrolidine-2-carboxamide
L-prolinamide
| Conditions | Yield |
|---|---|
| With hydrogen; palladium dihydroxide In ethanol; ethyl acetate at 20℃; under 760 Torr; for 14h; | 77% |
(S)-(9H-fluoren-9-yl)methyl 2-carbamoylpyrrolidine-1-carboxylate
L-prolinamide
| Conditions | Yield |
|---|---|
| With morpholine In N,N-dimethyl-formamide for 1h; | 73% |
| With alkylamine In N,N-dimethyl-formamide at 20℃; for 1h; |
| Conditions | Yield |
|---|---|
| Stage #1: L-proline With thionyl chloride In methanol for 2h; Heating; Stage #2: With ammonia In methanol at 20℃; for 96h; Further stages.; | 72% |
| Multi-step reaction with 3 steps 1: sodium hydroxide / H2O / Ambient temperature 2: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 3: 88.4 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature View Scheme | |
| Multi-step reaction with 2 steps 1: thionyl chloride / -5 - 70 °C 2: ammonium hydroxide / butan-1-ol / 5 - 30 °C View Scheme |
| Conditions | Yield |
|---|---|
| With ammonium acetate anodic oxidation; Pt electrodes, i = 370 mA*cm-2, current equiv.: 6.2 F/mol; | A 49% B 41% |
| Conditions | Yield |
|---|---|
| With methanol; ammonia |
(S)-2-Carbamoyl-pyrrolidine-1-carboxylic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester
A
1-(4-methoxyphenyl)ethanone
B
L-prolinamide
| Conditions | Yield |
|---|---|
| Irradiation; mild conditions; |
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IUPAC Name of L-Prolinamide (CAS NO.7531-52-4): pyrrolidine-2-carboxamide
Molecular Formula: C5H10N2O
Molecular Weight: 114.15 g/mol
Following is the molecular structure of L-Prolinamide (CAS NO.7531-52-4):
BRN: 80807
EINECS: 231-397-0
Density: 1.106 g/cm3
Flash Point: 137.4 °C
Index of Refraction: 1.491
Melting Point: 95-97 °C(lit.)
Surface Tension: 41.4 dyne/cm
Solubility in water: Very soluble
Enthalpy of Vaporization: 54.39 kJ/mol
Boiling Point: 303.6 °C at 760 mmHg
Vapour Pressure: 0.000923 mmHg at 25 °C
Appearance: white to off-white microcrystalline powder
Product Categories: Aminoacids Derivatives;APIs;Amino Acids;Proline [Pro, P];Amino Acids and Derivatives;Amides (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Amino Acid Derivatives;Peptide Synthesis;Proline
L-Prolinamide (CAS NO.7531-52-4) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.
Safty informations about L-Prolinamide (7531-52-4):
Hazard Codes: 
Xn ( Harmful)
Risk Statements: 22-36/37/38
R22:Harmful if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25
S22:Do not breathe dust
S24/25:Avoid contact with skin and eyes
WGK Germany: 3
L-Prolinamide , its cas register number is 7531-52-4. It also can be called Proline-nh2 ; Prolinamide ; (s)-Pyrrolidine-2-carboxylic acid amide ; (s)-Prolinamide ; H-Pro-nh2 ; L-Proline amide ; L-(-)-Prolinamide;l-prolinamide .
L-Prolinamide (CAS NO.7531-52-4) is stable under normal temperatures and pressures. L-Prolinamide (CAS NO.7531-52-4) should avoid the condition like incompatible materials. It is incompatible with other materials strong oxidizing agents. Its hazardous decomposition products are nitrogen oxides, carbon monoxide, carbon dioxide. Its hazardous polymerization has not been reported.
