(2-Iodo-1,1-dimethoxyethyl)benzene

Base Information

• Chemical Name: (2-Iodo-1,1-dimethoxyethyl)benzene
• CAS No.: 62054-83-5
• Molecular Formula: C10H13IO2
• Molecular Weight: 292.117
• DSSTox Substance ID: DTXSID40492460
• Nikkaji Number: J2.585.509D
• Wikidata: Q82338380
• Mol file: 62054-83-5.mol

Synonyms:(2-Iodo-1,1-dimethoxyethyl)benzene;62054-83-5;DTXSID40492460

Chemical Property of (2-Iodo-1,1-dimethoxyethyl)benzene

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 291.99603
• Heavy Atom Count: 13
• Complexity: 140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(CI)(C1=CC=CC=C1)OC

Technology Process of (2-Iodo-1,1-dimethoxyethyl)benzene

There total 6 articles about (2-Iodo-1,1-dimethoxyethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanol (67-56-1) + α-methoxystyrene (4747-13-1) → iodoacetophenone (4636-16-2) + (2-Iodo-1,1-dimethoxy-ethyl)-benzene (62054-83-5)

Guidance literature:

With iodine; silver nitrate; Ambient temperature;

Reference yield: 73.0%

acetophenone (98-86-2) + trimethyl orthoformate (149-73-5) → (2-Iodo-1,1-dimethoxy-ethyl)-benzene (62054-83-5)

Guidance literature:

With iodine; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2008.03.151

Reference yield:

2-methoxy-2-phenylethyl iodide (13684-98-5) → (2-Iodo-1,1-dimethoxy-ethyl)-benzene (62054-83-5)

Guidance literature:

Multi-step reaction with 3 steps

2: I₂, AgNO₃ / Ambient temperature

3: toluene-p-sulphonic acid / methanol / 1 h / Heating

With iodine; toluene-4-sulfonic acid; silver nitrate; In methanol;

upstream raw materials:

methanol

α-methoxystyrene

iodoacetophenone

trimethyl orthoformate

Downstream raw materials:

iodoacetophenone

methyl 2-chloro-2-phenylethanoate

1-chloroacetophenone

acetophenone