2,6-Dichloro-4-methoxyaniline

Base Information

• Chemical Name: 2,6-Dichloro-4-methoxyaniline
• CAS No.: 6480-66-6
• Molecular Formula: C7H7Cl2NO
• Molecular Weight: 192.045
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID70496799
• Nikkaji Number: J60.218C
• Wikidata: Q72466639
• Mol file: 6480-66-6.mol

Synonyms:2,6-dichloro-4-methoxyaniline;6480-66-6;2,6-dichloro-4-methoxybenzenamine;MFCD00115065;Benzenamine, 2,6-dichloro-4-methoxy-;3,5-dichloroanisidine;SCHEMBL3006255;DTXSID70496799;YWADYUWJRWZMSS-UHFFFAOYSA-N;AKOS006275723;MB00689;(2,6-dichloro-4-methoxy-phenyl)-amine;2 pound not6-Dichloro-4-methoxyaniline;AS-59963;SY114950;AM20040953;CS-0099466;FT-0660820;A846715

Chemical Property of 2,6-Dichloro-4-methoxyaniline

Chemical Property:

• Melting Point: 71oC
• Boiling Point: 267oC
• PKA: 1.31±0.10(Predicted)
• Flash Point: 115oC
• PSA: 35.25000
• Density: 1.375
• LogP: 3.16540
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 190.9904692
• Heavy Atom Count: 11
• Complexity: 122

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dichloro-4-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)Cl)N)Cl
• Uses: 2,6-Dichloro-4-methoxyaniline (cas# 6480-66-6) is a compound useful in organic synthesis.

Technology Process of 2,6-Dichloro-4-methoxyaniline

There total 14 articles about 2,6-Dichloro-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,5-dichloro-4-nitroanisole (100948-83-2) → 2,6-dichloro-4-methoxyaniline (6480-66-6)

Guidance literature:

With sodium dithionite; In ethanol; water; for 14h; Heating;

DOI:10.1055/s-0030-1258454

Reference yield: 45.0%

methanol (67-56-1) + p-benzoquinone oxime (637-62-7) → 2,6-dichloro-4-methoxyaniline (6480-66-6) + 6-amino-5-chloro-1,3-dimethoxybenzene (82485-84-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; at -10 - 0 ℃; for 1h;

DOI:10.1021/jm030891w

Reference yield:

3,5-dichlorophenol (591-35-5) + dimethyl sulfate (77-78-1) → 2,6-dichloro-4-methoxyaniline (6480-66-6) + 2,4-dichloro-6-methoxyaniline (93839-14-6)

Guidance literature:

3,5-dichlorophenol; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃;

With aniline; sodium hydroxide; In water;

dimethyl sulfate; Further stages;

DOI:10.1055/s-0030-1258454

upstream raw materials:

p-benzoquinone oxime

3,5-dichloro-4-nitroanisole

3-chloro-4-nitroanisole

4-methoxy-aniline

Downstream raw materials:

chloro-acetic acid-(2,6-dichloro-4-methoxy-anilide)

2-[2-(2',6'-dichloro-4'-methoxyphenylamino)phenyl]-N,N-dimethylacetamide

2,3,5-trichloro-4-iodoanisole

(2,6-dichloro-4-methoxyphenyl)[2H₅]phenylamine