Oxazole, 2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-

Base Information

Chemical Name:Oxazole, 2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-
CAS No.:66464-26-4
Molecular Formula:C11H11F2NO
Molecular Weight:211.211
Hs Code.:
DSSTox Substance ID:DTXSID00450905
Nikkaji Number:J951.339F
Wikidata:Q82270743

Synonyms:66464-26-4;2-(2,6-Difluorophenyl)-4,4-dimethyl-4,5-dihydrooxazole;Oxazole, 2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-;MFCD27927162;2-(2,6-difluorophenyl)-4,4-dimethyl-2-oxazoline;2-(2,6-difluorophenyl)-4,4-dimethyl-5H-1,3-oxazole;SCHEMBL2886677;DTXSID00450905;PJTVMGSOYRAPIP-UHFFFAOYSA-N;AC6562;SY248606;2-(2,6-difluorophenyl)-4,4-dimethyloxazoline;2-(2,6-Difluorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

Suppliers and Price of Oxazole, 2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of Oxazole, 2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:211.08087030
Heavy Atom Count:15
Complexity:268

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(COC(=N1)C2=C(C=CC=C2F)F)C

Technology Process of Oxazole, 2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-

There total 14 articles about Oxazole, 2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 150079-31-5
N-(2-hydroxy-1,1-dimethylethyl)-2,6-difluorobenzamide

: 66464-26-4
2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-1,3-oxazole

Guidance literature:: N-(2-hydroxy-1,1-dimethylethyl)-2,6-difluorobenzamide; With thionyl chloride; In dichloromethane; at 0 ℃; for 1h;

With sodium hydroxide; In water;

Reference yield: 88.0%

: ice water-cooled thionyl chloride

: 150079-31-5
N-(2-hydroxy-1,1-dimethylethyl)-2,6-difluorobenzamide

: 124-68-5
2-Amino-2-methyl-1-propanol

: 18063-02-0
2,6-difluorobenzoylchloride

: 66464-26-4
2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-1,3-oxazole

Guidance literature:: In dichloromethane;

Reference yield: 46.0%

: 19312-06-2
4,5-dihydro-4,4-dimethyl-2-phenoxazole

: 66464-20-8
2-(2-fluorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

: 66464-26-4
2-(2,6-difluorophenyl)-4,5-dihydro-4,4-dimethyl-1,3-oxazole

Guidance literature:: With palladium (II) nitrate; silver nitrate; N-fluorobis(benzenesulfon)imide; In acetonitrile; at 80 ℃; for 24h; Inert atmosphere; Microwave irradiation; Sealed tube;
DOI:10.1016/j.tetlet.2016.10.079