2,4-dichloro-1-isopropoxybenzene

Base Information

• Chemical Name: 2,4-dichloro-1-isopropoxybenzene
• CAS No.: 6851-40-7
• Molecular Formula: C9H10Cl2O
• Molecular Weight: 205.084
• Mol file: 6851-40-7.mol

Synonyms:2.4-Dichlor-1-isopropyloxy-benzol;2,4-dichloro-1-isopropoxybenzene;

Chemical Property of 2,4-dichloro-1-isopropoxybenzene

Chemical Property:

• Boiling Point: 250.5±20.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.201±0.06 g/cm3(Predicted)
• LogP: 3.78060

Purity/Quality:

95% ^*data from raw suppliers

2,4-dichloro-1-isopropoxybenzene 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-1-isopropoxybenzene

There total 4 articles about 2,4-dichloro-1-isopropoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,3-dichloro-4-fluorobenzene (1435-48-9) + isopropyl alcohol (67-63-0,8013-70-5) → 2,4-dichloro-1-isopropoxybenzene (6851-40-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane; at 40 ℃; for 48h; Irradiation;

DOI:10.1002/ejoc.202000337

Reference yield:

3-[2,4-dichloro-5-(1-methylethoxy)phenyl]-5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2(3H)-one (19666-30-9) → 2,4-dichloro-1-isopropoxybenzene (6851-40-7) + 1-trimethylacetyl-2-(2,4-dichloro-5-isopropoxyphenyl) hydrazine (51167-18-1) + 1-(2,4-dichloro-5-isopropoxyphenyl)-1-(methoxycarbonyl)-1,2-trimethylacetyl hydrazine (56578-26-8)

Guidance literature:

In methanol; water; at 28 ℃; Fusarium solani (Mortius) Sacc_.; also in the presence of dextrose; rate of degradation;

DOI:10.1021/jf00059a035

Reference yield:

isopropyl bromide (75-26-3) + 2,4-dichlorophenol (120-83-2,40477-79-0) → 2,4-dichloro-1-isopropoxybenzene (6851-40-7)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1016/j.bmcl.2014.11.008

upstream raw materials:

2-iodo-propane

2,4-dichlorophenol

3-[2,4-dichloro-5-(1-methylethoxy)phenyl]-5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2(3H)-one

isopropyl bromide

Refernces

• 1、 Labadie, Sharada,Dragovich, Peter S.,Chen, Jinhua,Fauber, Benjamin P.,Boggs, Jason,Corson, Laura B.,Ding, Charles Z.,Eigenbrot, Charles,Ge, Hongxiu,Ho, Qunh,Lai, Kwong Wah,Ma, Shuguang,Malek, Shiva,Peterson, David,Purkey, Hans E.,Robarge, Kirk,Salphati, Laurent,Sideris, Steven,Ultsch, Mark,Vanderporten, Erica,Wei, Binqing,Xu, Qing,Yen, Ivana,Yue, Qin,Zhang, Huihui,Zhang, Xuying,Zhou, Aihe. "Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase". . p. 75 - 82. Retrieved 2015/02/19.