(4-Methoxyphenyl)methyl-trimethylazanium;iodide

Base Information

• Chemical Name: (4-Methoxyphenyl)methyl-trimethylazanium;iodide
• CAS No.: 17734-35-9
• Molecular Formula: C11H18NO+
• Molecular Weight: 307.175
• NSC Number: 176934
• DSSTox Substance ID: DTXSID50938925
• Mol file: 17734-35-9.mol

Synonyms:17734-35-9;DTXSID50938925;NSC176934;NSC-176934;(4-Methoxyphenyl)-N,N,N-trimethylmethanaminium iodide

Chemical Property of (4-Methoxyphenyl)methyl-trimethylazanium;iodide

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 307.04331
• Heavy Atom Count: 14
• Complexity: 143

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C[N+](C)(C)CC1=CC=C(C=C1)OC.[I-]

Technology Process of (4-Methoxyphenyl)methyl-trimethylazanium;iodide

There total 4 articles about (4-Methoxyphenyl)methyl-trimethylazanium;iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N,N-dimethyl-4-methoxylbenzylamine (15175-54-9) + methyl iodide (74-88-4) → 1-(4-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide (17734-35-9)

Guidance literature:

In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.0c01274

Reference yield:

4-methoxy-benzylamine (2393-23-9) + methyl iodide (74-88-4) → 1-(4-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide (17734-35-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1021/jm9000242

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 1-(4-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide (17734-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid

2: ethanol

In formic acid; ethanol;

DOI:10.1016/S0040-4020(01)88438-6

upstream raw materials:

N,N-dimethyl-4-methoxylbenzylamine

methyl iodide

4-methoxy-benzaldehyde

p-methoxybenzyl chloride

Downstream raw materials:

p-methoxybenzylnitrile

p-methoxybenzylphenylsulfone

1-methoxy-4-(tosylmethyl)benzene

4,4'-dianisylmethane

Refernces

• 1、 Zhu, Haibo,Zhang, Yingying,Liu, Yishuai,Yang, Liu,Xie, Zongbo,Jiang, Guofang,Le, Zhang-Gao. "A general and practical sulfonylation of benzylic ammonium salts with sulfonyl hydrazides for the synthesis of sulfones". supporting information. . Retrieved 2020/05/06.
• 2、 Berrier, C.,Jacquesy, J. C.,Gesson, J. P.,Renoux, A.. "CYCLISATION DE DIARYLALCANES EN MILIEU SUPERACIDE: SYNTHESE DE CETONES TRICYCLIQUES A METHYLE ANGULAIRE ET MECANISME DE LEUR ISOMERISATION". . p. 1983 - 1994. Retrieved 2007/10/02.