2-Ethyl-6-methylpyrazine

Base Information

• Chemical Name: 2-Ethyl-6-methylpyrazine
• CAS No.: 13925-03-6
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933990090
• European Community (EC) Number: 237-692-0
• UNII: A9BL9OKQ7T
• DSSTox Substance ID: DTXSID60160977
• Nikkaji Number: J121.830A
• Wikidata: Q27273802
• Metabolomics Workbench ID: 49425
• ChEMBL ID: CHEMBL4522941
• Mol file: 13925-03-6.mol

Synonyms:2-ETHYL-6-METHYLPYRAZINE;13925-03-6;Pyrazine, 2-ethyl-6-methyl-;2-Methyl-6-ethylpyrazine;2,6-Methylethylpyrazine;UNII-A9BL9OKQ7T;A9BL9OKQ7T;2-ethyl-6-methyl pyrazine;Pyrazine, 6-ethyl-2-methyl;EINECS 237-692-0;PYRAZINE,2-ETHYL-6-METHYL-;2-Ehtyl-6-methylpirazine;2-ethyl-6-methyl-pyrazine;SCHEMBL105987;CHEMBL4522941;FEMA NO. 3919;FEMA 3919;6-METHYL-2-ETHYLPYRAZINE;DTXSID60160977;CHEBI:193621;MFCD00055035;AKOS006283739;2-ETHYL-6-METHYLPYRAZINE [FHFI];DS-20136;CS-0161293;FT-0766389;D84033;EN300-300011;Q27273802

Chemical Property of 2-Ethyl-6-methylpyrazine

Chemical Property:

• Appearance/Colour: colourless to slightly yellow liquid with a roasted baked potato odour
• Vapor Pressure: 1.98mmHg at 25°C
• Melting Point: 57-63 °C
• Refractive Index: 1.5
• Boiling Point: 170.2 °C at 760 mmHg
• PKA: 2.40±0.10(Predicted)
• Flash Point: 62.7 °C
• PSA: 25.78000
• Density: 0.977 g/cm³
• LogP: 1.34740
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

99%, ^*data from raw suppliers

2-Ethyl-6-methylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=NC(=CN=C1)C
• Uses: 2-Ethyl-6-methylpyrazine is a volatile compound contributing to coffee flavor, aroma and sensory quality.

Technology Process of 2-Ethyl-6-methylpyrazine

There total 28 articles about 2-Ethyl-6-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-glucose (50-99-7) + H-Lys-Lys-OH hydrochloride (134276-45-2) → 1,4-pyrazine (290-37-9) + 2-Methylpyrazine (109-08-0) + 2,5-dimethyl-pyrazine (123-32-0) + 2,3-dimethylpyrazine (5910-89-4) + 2-ethyl-3,6-dimethylpyrazine (13360-65-1) + 2,6-dimethylpyrazine (108-50-9) + 2,3,5-trimethylpyrazine (14667-55-1) + 3-ethenyl-2,5-dimethylpyrazine (80935-98-4) + 2-ethyl-6-methylpyrazine (13925-03-6)

Guidance literature:

In water; at 130 ℃; for 2h; pH=8;

DOI:10.1021/jf903898t

Reference yield:

D-glucose (50-99-7) + LysAla*hydrobromide (410538-35-1) → 1,4-pyrazine (290-37-9) + 2-Methylpyrazine (109-08-0) + 2,5-dimethyl-pyrazine (123-32-0) + 2,3-dimethylpyrazine (5910-89-4) + 2-ethyl-3,6-dimethylpyrazine (13360-65-1) + 2,6-dimethylpyrazine (108-50-9) + 2,3,5-trimethylpyrazine (14667-55-1) + 2-ethyl-6-methylpyrazine (13925-03-6) + 2-ethyl-5-methypyrazine (13360-64-0) + 5-ethyl-2,3-dimethylpyrazine (15707-34-3)

Guidance literature:

In water; at 130 ℃; for 2h; pH=8;

DOI:10.1021/jf903898t

Reference yield:

D-glucose (50-99-7) + LysLeu*acetate (103404-72-4) → 1,4-pyrazine (290-37-9) + 2-Methylpyrazine (109-08-0) + 2,5-dimethyl-pyrazine (123-32-0) + 2,3-dimethylpyrazine (5910-89-4) + 2-ethyl-3,6-dimethylpyrazine (13360-65-1) + 2,6-dimethylpyrazine (108-50-9) + 2,3,5-trimethylpyrazine (14667-55-1) + 2-ethyl-6-methylpyrazine (13925-03-6) + 2-ethyl-3,5-dimethylpyrazine (13925-07-0) + 2-ethyl-5-methypyrazine (13360-64-0)

Guidance literature:

In water; at 130 ℃; for 2h; pH=8;

DOI:10.1021/jf903898t

upstream raw materials:

L-serin

D-Glucose

L-alanin

tert-butyl 2-(hydroxyimino)butyl(prop-2-ynyl)carbamate

Refernces

• 1、 Van Lancker, Fien,Adams,De Kimpe, Norbert. "Formation of pyrazines in maillard model systems of lysine-containing dipeptides". scheme or table. p. 2470 - 2478. Retrieved 2010/09/04.
• 2、 Rizk, Toni,Bilodeau, Eric J.-F.,Beauchemin, Andre M.. "Synthesis of pyridines and pyrazines using an intramolecular hydroamination-based reaction sequence". supporting information; experimental part. p. 8325 - 8327. Retrieved 2010/01/16.