N,N-Dimethylglycine ethyl ester

Base Information

• Chemical Name: N,N-Dimethylglycine ethyl ester
• CAS No.: 33229-89-9
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Hs Code.: 29224999
• European Community (EC) Number: 251-411-9
• DSSTox Substance ID: DTXSID6067755
• Nikkaji Number: J149.686G
• Wikidata: Q81994400
• Mol file: 33229-89-9.mol

Synonyms:N,N-Dimethylglycine ethyl ester;33229-89-9;ethyl 2-(dimethylamino)acetate;Glycine, N,N-dimethyl-, ethyl ester;Dimethylglycine ethyl ester;Ethyl dimethylglycinate;Ethyl N,N-dimethylglycinate;Ethyl (dimethylamino)acetate;Ethyl N,N-dimethylaminoacetate;Di-Me-Gly-OEt;EINECS 251-411-9;BRN 1750085;AI3-62123;4-04-00-02366 (Beilstein Handbook Reference);N,N-Dimethylglycineethylester;N,N-Dimethyl-glycine ethyl ester;N,N-Dimethylglycine ethyl;SCHEMBL196815;DTXSID6067755;BGCNBOFPABQGNG-UHFFFAOYSA-;n,n-dimethyl glycine ethyl ester;AMY3944;Dimethylamino-acetic acid ethyl ester;MFCD00009175;AKOS003961598;CS-W013421;HY-W012705;N,N-Dimethylglycine ethyl ester, 98%;LS-72560;D0726;D78232

Chemical Property of N,N-Dimethylglycine ethyl ester

Chemical Property:

• Appearance/Colour: colourless to slightly yellow-green liquid
• Vapor Pressure: 3.83mmHg at 25°C
• Melting Point: 135 °C
• Refractive Index: n20/D 1.413(lit.)
• Boiling Point: 150.5 °C at 760 mmHg
• PKA: 7.37±0.28(Predicted)
• Flash Point: 46.2 °C
• PSA: 29.54000
• Density: 0.948 g/cm³
• LogP: 0.11110
• Storage Temp.: Flammables area
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 91.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-Dimethylglycine ethyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, F
• Hazard Codes: Xi,F
• Statements: 10-38
• Safety Statements: 37-17-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=O)CN(C)C

Technology Process of N,N-Dimethylglycine ethyl ester

There total 8 articles about N,N-Dimethylglycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + GlyOEt*HCl (459-73-4) → N,N-dimethylglycine ethyl ester (33229-89-9)

Guidance literature:

With zinc(II) tetrahydroborate; zinc(II) chloride; In tetrahydrofuran; for 10h; Ambient temperature;

Reference yield: 62.0%

ethyl bromoacetate (105-36-2) + dimethyl amine (124-40-3) → N,N-dimethylglycine ethyl ester (33229-89-9)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃; for 16.1667h;

Reference yield: 51.0%

2-(dimethylamino)-2-oxoacetic acid ethyl ester (16703-52-9) → N,N-dimethylglycine ethyl ester (33229-89-9)

Guidance literature:

2-(dimethylamino)-2-oxoacetic acid ethyl ester; With triethyloxonium fluoroborate; In dichloromethane; for 16h;

With platinum on carbon; hydrogen; sodium ethanolate; In ethanol; at 25 ℃; for 16h; under 7500.75 Torr;

DOI:10.1002/cctc.201701287

upstream raw materials:

chloroacetic acid ethyl ester

dimethyl amine

formaldehyd

GlyOEt*HCl

Downstream raw materials:

(N,N-dimethyl-glycyl)-guanidine

N-<(ethoxycarbonyl)methyl>trimethylammonium chloride

ethyl [cyano(methyl)amino]acetate

dimethylaminoacetic acid

Refernces

• 1、 -. "SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH". Paragraph 00184. . Retrieved 2016/06/28.
• 2、 -. "Catalytic Hydrogenation for Producing Amines from Carboxylic Acid Amides, Carboxylic Acid Diamides, Di-, Tri-, or Polypeptides, or Peptide Amides". Paragraph 185-186. . Retrieved 2016/10/11.