BENZOIC ACID,4-BROMO-2,6-DIMETHYL-,METHYL ESTER

Base Information

• Chemical Name: BENZOIC ACID,4-BROMO-2,6-DIMETHYL-,METHYL ESTER
• CAS No.: 90841-46-6
• Molecular Formula: C10H11BrO2
• Molecular Weight: 243.1
• Hs Code.: 2916399090
• Mol file: 90841-46-6.mol

Synonyms:methyl 4-bromo-2,6-dimethyl-benzoate;Methyl-4-brom-2,6-dimethylbenzoat;Benzoic acid,4-bromo-2,6-dimethyl-,methyl ester;Y6484;4-Brom-2,6-dimethyl-benzoesaeure-methylester;4-bromo-2,6-dimethylbenzoic acid methyl ester;

Chemical Property of BENZOIC ACID,4-BROMO-2,6-DIMETHYL-,METHYL ESTER

Chemical Property:

• Boiling Point: 285.1±35.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.380±0.06 g/cm3(Predicted)
• LogP: 2.85250
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

Methyl4-Bromo-2,6-dimethylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZOIC ACID,4-BROMO-2,6-DIMETHYL-,METHYL ESTER

There total 5 articles about BENZOIC ACID,4-BROMO-2,6-DIMETHYL-,METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2,6-dimethylbenzoic acid (74346-19-3) + methyl iodide (74-88-4) → methyl 4-bromo-2,6-dimethylbenzoate (90841-46-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield:

methanol (67-56-1) + 4-bromo-2,6-dimethylphenyl trifluoromethanesulfonate (851335-23-4) + carbon monoxide (201230-82-2) → methyl 4-bromo-2,6-dimethylbenzoate (90841-46-6)

Guidance literature:

With triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In dimethyl sulfoxide; at 75 ℃;

Reference yield:

→ methyl 4-bromo-2,6-dimethylbenzoate (90841-46-6)

Guidance literature:

With mercury dibromide; Erwaermen des Diazoniumsalzes mit NaBr;

DOI:10.1021/ja01632a045

upstream raw materials:

methanol

4-bromo-2,6-dimethylphenyl trifluoromethanesulfonate

carbon monoxide

4-bromo-2,6-dimethylbenzoic acid

Downstream raw materials:

methyl 4-bromo-2-(bromomethyl)-6-methylbenzoate

Refernces

• 1、 -. "BIOREVERSABLE PROMOIETIES FOR NITROGEN-CONTAINING AND HYDROXYL-CONTAINING DRUGS". Page/Page column 141. . Retrieved 2015/06/18.
• 2、 -. "AMINO ALCOHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USE OF THESE". Page/Page column 36-37. . Retrieved 2008/06/13.